Daily Journal Digest — 2026-07-18¶
過去 24 小時新增：Transplant ID × 22、One Health × 11、Food Security × 11，共 44 篇。
⭐ 今日亮點¶
- Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs
One Health AMR 監測框架升級 - From the lungs and beyond: host-fungal interactions in disseminated aspergillosis
侵襲性黴菌散播機轉核心綜述 - Characteristics of Mortality in HIV-negative Cryptococcosis Patients: Analysis of a Cohort of 743 Patients
HIV-negative cryptococcosis風險分
🔬 深入評讀¶
Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs¶
mSphere | IF 3.7 | DOI | PMID 42466908
- 設計：這是 mSphere 的 mini-review／Perspective 型文章，不是原始實證研究；作者據 47 篇文獻與 1 個整理表，從 One Health 角度討論 human、animal、environment 之間 plasmid-mediated AMR 的傳播機制與監測缺口。文中未設定單一研究期間、國家或追蹤設計，而是整合 wastewater、river、seawater、livestock、birds、clinical isolates 等跨部門資料。
- 樣本：沒有可計算的 n 或追蹤時間；核心證據來自 Table 1 彙整的 12 類 plasmid groups，包括 IncA/C、IncF、IncHI1、IncHI2、IncI complex、IncN、IncP、IncQ、IncR、IncU、IncX 與 Col-type。涵蓋的宿主／場域包括 Escherichia coli、Klebsiella pneumoniae、Vibrio cholerae O1/O139、Aeromonas spp.、Salmonella enterica ser. Wandsworth，以及臨床病人、鳥類、豬、屠宰場、河川、海水／沙灘、WWTP influent／effluent／biosolid。
- 關鍵論點：主要訊息是 ARG 的風險不只取決於基因是否存在，而取決於是否位在可移動 plasmid 上；文中點名 IncF、IncA/C、IncHI2、IncN、IncI 為跨 One Health 部門反覆出現的核心 plasmid families。具體例子包括 IncL-blaOXA-48、IncX3/IncFII-blaNDM variants、IncFII/IncR-blaKPC-2，以及 IncI1 plasmids 帶 blaCTX-M／blaCMY；效應量不能用 HR／OR 表示，但跨宿主、跨環境、跨 ARG 類別的重複出現，支持「plasmid backbone」比單看 ARG abundance 更能代表傳播潛力。
- Limitation：主要限制是本文為敘述型 mini-review，沒有系統性搜尋策略、納入／排除標準、偏倚評估，也沒有 pooled estimate、HR、OR 或 CI。不同研究使用 PBRT、MOB／MPF typing、pMLST、whole-plasmid phylogeny、metagenomics 或 isolate WGS，解析度不一致，因此 Table 1 的 12 類 plasmid groups 適合做風險框架提示，不能直接推論各部門之間的傳播比例或方向。
- Bottom line：臨床與公衛監測若只看 E. coli 或 ARG abundance，會漏掉 IncF、IncA/C、IncHI2、IncN、IncI 這些真正驅動 ESBL、carbapenemase、mcr、quinolone、aminoglycoside resistance 跨 human-animal-environment 流動的 plasmid vehicles。
From the lungs and beyond: host-fungal interactions in disseminated aspergillosis¶
Curr Opin Microbiol | DOI | PMID 42462680
- 設計：這是敘述性綜述，聚焦 disseminated aspergillosis 中 Aspergillus fumigatus 與宿主血管介面的分子與細胞事件。摘要未交代研究期間、地區或系統性檢索方法。
- 樣本：本篇沒有原始病人樣本數、比較組或追蹤時間；涵蓋的主題包括 fungal morphogenesis、endothelial adhesion、vascular barrier penetration 與 hematogenous spread。
- 關鍵論點：作者指出 invasive aspergillosis 多以肺部疾病表現，但一部分病人會由肺部散播至次發感染部位，且 disseminated disease 預後明顯較 pulmonary infection 差。文章把臨床現象連回宿主－病原介面，強調血管內皮黏附與屏障穿透是理解血行性散播的關鍵環節。
- Limitation：這類機轉性綜述的限制是臨床可轉化性仍間接，摘要也未提供納入研究數、證據分級或不同模型間的一致性評估。從細胞與動物模型推回免疫低下病人的診斷、預防或治療策略，仍需要臨床資料補強。
- Bottom line：disseminated aspergillosis 不只是肺部感染變嚴重，而是涉及血管介面與真菌形態轉換的可研究病程。
Characteristics of Mortality in HIV-negative Cryptococcosis Patients: Analysis of a Cohort of 743 Patients¶
Open Forum Infect Dis | IF 3.9 | DOI | PMID 42466237
- 設計：這是一項HIV陰性cryptococcosis病人世代分析，使用臨床、實驗室與影像資料，以Kaplan-Meier估計2週、10週與1年全因死亡率，並用Cox model分析死亡相關因子。作者另納入近期4個大型世代做meta-analysis，比較不同地區HIV陰性cryptococcosis的2週死亡差異。
- 樣本：主世代包含743名HIV陰性cryptococcosis病人；摘要未交代研究期間、收案國家／地區、比較組細節與追蹤完整性。Meta-analysis部分聚焦近期4個大型世代，並探討西方國家與中國HIV陰性cryptococcosis病人的年齡與基礎風險族群差異。
- 關鍵數字：主世代2週、10週與1年死亡率分別為1.4%（95% CI 0.5–2.2%）、8.4%（95% CI 6.3–10.4%）與12.2%（95% CI 9.7–14.7%），死亡主要集中在2到10週。高齡、baseline modified Rankin Scale較高、意識改變、total bilirubin升高、周邊血白血球升高、albumin降低與creatinine升高皆與死亡相關；meta-analysis顯示solid organ transplant與malignancy為2週死亡風險因子（RR 1.50, 95% CI 1.08–2.07），meta-regression則指出西方世代較高年齡增加風險（RR 1.15, 95% CI 1.09–1.22）。
- Limitation：主要限制是觀察性世代，死亡相關因子可能受confounding、治療差異、疾病嚴重度與診斷流程差異影響；摘要未說明診斷是否adjudicate，也未提供抗黴菌治療、CNS involvement比例或免疫抑制細節。Meta-analysis僅納入4個近期大型世代，地區、族群與照護系統異質性可能使meta-regression推論不穩。
- Bottom line：HIV陰性cryptococcosis不是單一族群，年齡、神經功能、器官功能與免疫風險族群可協助早期辨識高死亡風險病人。
- GRADE 證據等級：Very low ⊕◯◯◯
🔴 Transplant & Opportunistic Infections¶
Englumafusp alfa plus glofitamab in B cell non-Hodgkin lymphoma: a phase 1 trial¶
Authors: Hutchings M et al. | Journal: Nat Med | Date: 2026 Jul 16
DOI: 10.1038/s41591-026-04533-0 | PMID: 42463852
TL;DR: 134名relapsed/refractory B-NHL接受englumafusp alfa加glofitamab；MTD未達，grade 3/4 AE 59.0%，C2D8 aggressive B-NHL ORR 68.7%、CMR 56.6%。
嘻嘻：B-NHL多一組打法，血液科今天有點亮。
Application of metagenomic next-generation sequencing in HIV-negative hematogenous disseminated tuberculosis¶
Authors: Luo L et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1851741 | PMID: 42465845
TL;DR: 10名HIV陰性hematogenous disseminated tuberculosis多有免疫受損與呼吸衰竭，blood mNGS於2–3天偵測Mycobacterium tuberculosis，可縮短診斷延遲。
嘻嘻：blood mNGS救場，TB少演幾天懸疑劇。
A meta-analysis-informed diagnostic stratification tool for invasive pulmonary aspergillosis in severe fever with thrombocytopenia syndrome: systematic review, meta-analysis, and single-center cohort-based assessment¶
Authors: Ma R et al. | Journal: Front Cell Infect Microbiol | Date: 2026
DOI: 10.3389/fcimb.2026.1747950 | PMID: 42465843
TL;DR: 6研究2,342名SFTS患者建構IPA/SAPA三變項分層工具；單中心220人驗證AUC 0.910，高風險組IPA/SAPA發生率83.6%，但仍需外部驗證。
嘻嘻：SFTS併IPA終於有點早期雷達感。
Population pharmacokinetics of ritonavir-boosted atazanavir in subsequent-line treatment in African children with HIV¶
Authors: van Dyk J et al. | Journal: Antimicrob Agents Chemother | Date: 2026 Jul 17
DOI: 10.1128/aac.00592-26 | PMID: 42467063
TL;DR: 70名非洲HIV兒童atazanavir/r population PK顯示現行每日一次劑量可達足量暴露；rifampicin共治模擬中，改每日兩次可恢復近似暴露。
嘻嘻：atazanavir/r劑量學幫小朋友撐住戰線。
Characteristics of Mortality in HIV-negative Cryptococcosis Patients: Analysis of a Cohort of 743 Patients¶
Authors: Dai K et al. | Journal: Open Forum Infect Dis | Date: 2026 Jul
DOI: 10.1093/ofid/ofag410 | PMID: 42466237
TL;DR: 743名HIV陰性cryptococcosis患者2週、10週、1年死亡率為1.4%、8.4%、12.2%；高齡、意識改變、bilirubin/creatinine升高與albumin低下增加死亡風險。
不嘻嘻：HIV陰性cryptococcosis也很會補刀。
Cryptic clues from an acute abdomen: a case report of peritonitis turning into disseminated cryptococcosis¶
Authors: Boloor A et al. | Journal: BMC Infect Dis | Date: 2026 Jul 16
DOI: 10.1186/s12879-026-13871-w | PMID: 42464077
TL;DR: 一名新診斷advanced HIV、CD4 98 cells/mm³女性以急性腹膜炎表現，術後確認disseminated cryptococcosis併meningitis，amphotericin B後恢復。
嘻嘻：腹膜炎開場，cryptococcosis硬是反轉成教案。
Impact of CMV infection on pediatric allogeneic HSCT outcomes in a region of high CMV seroprevalence: a non-TBI cohort study¶
Authors: Karimzadeh A et al. | Journal: Cytotherapy | Date: 2026 May 19
DOI: 10.1016/j.jcyt.2026.102909 | PMID: 42462593
TL;DR: 514名兒童non-TBI allo-HSCT中CMV infection發生率57%，與aGVHD及grade III–IV aGVHD風險增加相關；CMV先於aGVHD者5年OS較差。
不嘻嘻：CMV在兒童HSCT還是很會添亂。
'Why should I start medication when I am not feeling sick?' A qualitative study of refusal, initiation, completion and discontinuation of tuberculosis preventive treatment among people living with HIV in sub-Saharan Africa¶
Authors: Tsope L et al. | Journal: BMJ Public Health | Date: 2026
DOI: 10.1136/bmjph-2025-004163 | PMID: 42466460
TL;DR: 撒哈拉以南非洲141名HIV感染者訪談顯示，TPT拒用或中斷多因無症狀困惑、副作用、pill burden與禁忌；社會支持與醫療人員互動促進完成。
不嘻嘻：沒症狀要吃藥，衛教永遠是地獄副本。
A 24-Year-Old Man with Disseminated Tuberculosis and A Corticosteroid-Refractory Paradoxical Reaction to Anti-Tuberculous Treatment¶
Authors: Charalampidis C et al. | Journal: Eur J Case Rep Intern Med | Date: 2026
DOI: 10.12890/2026_006001 | PMID: 42466226
TL;DR: 24歲免疫正常男性disseminated tuberculosis治療後paradoxical reaction持續發燒且corticosteroid無效；anakinra作salvage therapy後快速退燒、影像改善。
嘻嘻：anakinra把paradoxical reaction按下暫停鍵。
Diagnostic accuracy and acceptability of self- and health worker-collected tongue swabs for Mycobacterium tuberculosis complex detection in adults in South Africa¶
Authors: David A et al. | Journal: medRxiv | Date: 2026 Jul 06
DOI: 10.64898/2026.07.04.26357275 | PMID: 42465934
TL;DR: 南非高TB/HIV負擔場域中，self-與health worker-collected tongue swab用Ultra偵測MTBC sensitivity皆68%，高於smear 46%，且>90%受試者接受自採。
嘻嘻：tongue swab自採，TB篩檢終於比較像現代生活。
Predicting radiological severity of pulmonary tuberculosis in children: an assessment of the WHO-criteria and novel prediction scores on an individual participant dataset¶
Authors: Gupta A et al. | Journal: medRxiv | Date: 2026 Jul 10
DOI: 10.64898/2026.07.07.26357441 | PMID: 42465924
TL;DR: 2,383名兒童TB IPD顯示無CXR的WHO criteria辨識放射學嚴重肺TB sensitivity僅21.7–30.1%；新score較佳但仍suboptimal，短療程分流困難。
不嘻嘻：兒童TB分流還是離不開CXR這根拐杖。
Transplant Outcomes and Weight Management in Renal Disease Study¶
Authors: Lalwani M et al. | Journal: Indian J Transpl | Date: 2025 Jul
DOI: 10.4103/ijot.ijot_33_25 | PMID: 42465872
TL;DR: 716名印度南部renal transplant recipients追蹤10年，末次追蹤顯著增重與較佳graft及patient survival相關；但達class II obesity則patient survival較差。
不嘻嘻：移植後體重題，連好消息都附帶但書。
Molecular signaling in coinfection: how M. tuberculosis and respiratory viruses rewire host immunity and alter TB outcomes¶
Authors: Feya Q et al. | Journal: Front Immunol | Date: 2026
DOI: 10.3389/fimmu.2026.1863302 | PMID: 42465772
TL;DR: TB與呼吸道病毒coinfection會經TLR、RIG-I、cGAS-STING與IFN-I等路徑重塑granuloma與Th1/Th17反應；結局取決於病毒量、時序與TB stage。
不嘻嘻：TB遇上呼吸道病毒，免疫系統直接多工過載。
Pulmonary Nocardiosis Diagnosed by Plasma Metagenomic Next-Generation Sequencing in a Patient With Recurrent Febrile Neutropenia¶
Authors: Vega Brizneda M et al. | Journal: Case Rep Infect Dis | Date: 2026
DOI: 10.1155/crdi/2832247 | PMID: 42465527
TL;DR: 87歲MDS併長期neutropenia患者反覆febrile neutropenia，常規檢驗未果；plasma mNGS偵測N. farcinica後啟動anti-Nocardia治療並退燒。
嘻嘻：plasma mNGS又一次把Nocardia抓出來。
Monocyte-amplified transcriptional signatures of human diseases¶
Authors: Arrieta-Ortiz ML et al. | Journal: bioRxiv | Date: 2026 Jul 06
DOI: 10.64898/2026.07.04.736372 | PMID: 42465435
TL;DR: monocyteMINER以1,202名健康者monocyte transcriptome建網絡；5-gene TB signature在18 cohorts、>4,400人中優於77個既有signature，且可預測5年內TB進展。
嘻嘻：5 genes就能預警TB，這工具有點香。
NK-like and networked CD8 + T cell immunity mediates exceptional HIV control¶
Authors: Alrubayyi A et al. | Journal: bioRxiv | Date: 2026 Jul 07
DOI: 10.64898/2026.07.02.735504 | PMID: 42465352
TL;DR: exceptional HIV controllers富集NK-like KIR⁺ CD8⁺ T cells與networked HIV epitope targeting；移除KIR⁺ CD8⁺ T cells會削弱autologous感染細胞清除。
嘻嘻：HIV controller的CD8戰隊真的很會打。
Paradoxical Th1 activation and CTLA-4 regulation is beneficial during latent cryptococcosis¶
Authors: Ding M et al. | Journal: bioRxiv | Date: 2026 Jul 06
DOI: 10.64898/2026.07.02.736061 | PMID: 42465329
TL;DR: 小鼠latent C. neoformans肺感染中，Th1-like CD4 T cells足以控制真菌；CTLA-4 blockade反使真菌增殖，提示CTLA-4抑制有害Th2反應有保護性。
嘻嘻：CTLA-4在latent Cryptococcus竟是守門員。
Analysis of tuberculosis and multiple diseases as co-morbidities: a narrative review¶
Authors: Sun Y et al. | Journal: Ann Med | Date: 2026 Dec
DOI: 10.1080/07853890.2026.2702807 | PMID: 42464522
TL;DR: TB合併DM、HIV、COPD或lung cancer會透過免疫失調、慢性發炎與oxidative stress增加感染、診斷與治療複雜度；需雙向篩檢與整合照護。
不嘻嘻：TB共病照護，永遠不是單線任務。
Unveiling Mucorales infections: A cutting-edge longitudinal imaging approach for real-time infection and host-response monitoring in Galleria mellonella and mouse models¶
Authors: Resendiz-Sharpe A et al. | Journal: Virulence | Date: 2026 Dec
DOI: 10.1080/21505594.2026.2688582 | PMID: 42464473
TL;DR: 建立bioluminescent Mucor lusitanicus於Galleria mellonella與mouse mucormycosis模型，結合micro-CT可縱向量化fungal burden與宿主組織反應。
嘻嘻：mucormycosis模型會發光，追蹤終於比較不瞎。
Safety and efficacy of inhaled itraconazole in adults with asthma and allergic bronchopulmonary aspergillosis (PUR1900-ABPA): a randomized, double-blind, parallel group, placebo-controlled, multicenter, phase 2 trial¶
Authors: Agarwal R et al. | Journal: Eur Respir J | Date: 2026 Jul 16
DOI: 10.1183/13993003.00058-2026 | PMID: 42463270
TL;DR: 43名asthma併ABPA成人phase 2試驗中，inhaled PUR1900 40 mg治療16週改善FEV1 +0.28 L與ACQ-7 -0.51，AE 31%且無serious AE。
嘻嘻：inhaled itraconazole讓ABPA治療多點想像。
From the lungs and beyond: host-fungal interactions in disseminated aspergillosis¶
Authors: Sanchez D et al. | Journal: Curr Opin Microbiol | Date: 2026 Jul 16
DOI: 10.1016/j.mib.2026.102798 | PMID: 42462680
TL;DR: disseminated aspergillosis較pulmonary infection預後更差；Aspergillus fumigatus藉morphogenesis、endothelial adhesion與血管屏障穿透促進hematogenous spread。
不嘻嘻：Aspergillus一進血流，事情就開始難看。
Triazole resistance in clinical Aspergillus fumigatus isolates in India, a multicenter surveillance study¶
Authors: Paul RA et al. | Journal: Diagn Microbiol Infect Dis | Date: 2026 Jul 08
DOI: 10.1016/j.diagmicrobio.2026.117541 | PMID: 42462376
TL;DR: 印度518株臨床A. fumigatus中azole non-wildtype盛行率低於5%，voriconazole resistance 1.4%；但1994–2020年三種triazole MIC中位數上升。
不嘻嘻：azole抗藥性低歸低，MIC還是在悄悄爬。
🟢 One Health / Zoonoses¶
Hepatitis E virus in meat and meat products without liver contents - Detection methods, occurrence and implications for public health¶
Authors: Johne R et al. | Journal: Int J Food Microbiol | Date: 2026 Jul 11
DOI: 10.1016/j.ijfoodmicro.2026.111971 | PMID: 42462428
TL;DR: HEV RNA可於感染豬肌肉與野豬肉中偵測，raw sausage最高報告26%；生食或未熟肉品傳播風險低於含肝製品，但仍需標準化檢測與控制措施。
不嘻嘻：HEV提醒我們，肉沒熟真的別賭。
A novel penicillin-binding protein inhibitor with unprecedented intracellular activity eradicates multiple pathogenic bacteria¶
Authors: Guo KX et al. | Journal: PLoS Pathog | Date: 2026 Jul
DOI: 10.1371/journal.ppat.1014242 | PMID: 42461830
TL;DR: RS 17053重新定位為PBP inhibitor，對Brucella、Salmonella與MRSA MIC 0.25–4 μg/mL；小鼠zoonotic infection每日10 mg/kg降低器官菌量約2-log。
嘻嘻：老藥新靶點，PBP inhibitor又能上場。
Severe pneumonia and acute respiratory distress syndrome caused by avian influenza A (H10N3) in a young female: a case report¶
Authors: Zhao M et al. | Journal: Infection | Date: 2026 Jul 17
DOI: 10.1007/s15010-026-02883-y | PMID: 42467174
TL;DR: 23歲女性感染avian influenza A(H10N3)導致severe pneumonia與ARDS，需mechanical ventilation與VV ECMO；約3個月治療後出院，為第4例人類病例。
不嘻嘻：H10N3人類病例少，但一來就是重症套餐。
Persistent toxic elements in soil-water-food systems: food safety, implications, biomonitoring insights, and cumulative toxicological risk assessment¶
Authors: Shahid M | Journal: J Sci Food Agric | Date: 2026 Jul 16
DOI: 10.1002/jsfa.70872 | PMID: 42464039
TL;DR: arsenic、cadmium、lead、mercury等PTEs可經soil-water-food系統累積；現行單一污染物risk assessment低估bioavailability、mixture toxicity與多路徑慢性暴露。
不嘻嘻：重金屬暴露這題，食物鏈從不會放過人。
Characteristics of Staphylococcus lugdunensis isolated from humans and animals¶
Authors: Prorok P et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-62992-4 | PMID: 42463811
TL;DR: 人與伴侶動物來源S. lugdunensis isolates呈現多樣MLST、抗藥性與biofilm phenotype；biofilm受培養溫度與宿主來源影響，支持One Health監測。
不嘻嘻：S. lugdunensis也加入One Health複雜宇宙。
Seroprevalence of hepatitis E virus antibodies among slaughtered pigs in Nigeria: an abattoir-based multi-state survey¶
Authors: Ogundijo OA et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-59517-4 | PMID: 42463761
TL;DR: 奈及利亞6州1,723隻屠宰豬HEV抗體盛行率47.1%，Kaduna達67.6%；雌豬與>10月齡aOR皆3.23，屠宰衛生與zoonosis認知不足。
不嘻嘻：HEV在豬場高調存在，餐桌端壓力山大。
Silver nanoparticle hydrogen peroxide composite mitigates resistant Escherichia coli dissemination driven by poultry waste biosecurity failures¶
Authors: Badawy B et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-61245-8 | PMID: 42463747
TL;DR: 100座 poultry farms調查顯示80%農民缺AMR認知、90%無litter treatment；192份litter中E. coli盛行率72.4%，AgNPs-H2O2 MIC 3.125 µg/mL且24小時完全抑菌。
不嘻嘻：養禽廢棄物管理破洞，AMR就順風飛。
Environmental prevalence of enteric viruses across the covid-19 pandemic: A three-year monitoring study¶
Authors: Serra F et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-62813-8 | PMID: 42463591
TL;DR: 義大利坎帕尼亞500份沿岸海水樣本中44.0%至少一種enteric virus陽性；多數環境序列與當地臨床株相同或近緣，支持環境監測預警價值。
嘻嘻：海水監測會說話，疫情線索藏在浪裡。
Plasmid-mediated antimicrobial resistance across One Health sectors: transmission dynamics and surveillance needs¶
Authors: Fairusya N et al. | Journal: mSphere | Date: 2026 Jul 17
DOI: 10.1128/msphere.00192-26 | PMID: 42466908
TL;DR: AMR監測若只看ARG或isolate會忽略plasmid傳播；跨人、動物與環境反覆出現的Inc groups提示需納入plasmid-resolved analysis與wastewater surveillance。
不嘻嘻：plasmid才是AMR社交高手，監測別再漏看。
Cellular tropism of highly pathogenic avian influenza (HPAI) A(H5N1) clade 2.3.4.4b viruses in human respiratory and bovine mammary epithelial cells¶
Authors: Brock N et al. | Journal: Microbiol Spectr | Date: 2026 Jul 17
DOI: 10.1128/spectrum.01377-26 | PMID: 42466872
TL;DR: A(H5N1) clade 2.3.4.4b各genotype皆能在人類Calu-3細胞複製；B3.13在牛乳腺MAC-T細胞達較高titer並誘發較強innate immune genes。
不嘻嘻：H5N1跨物種練兵，旁觀者真的笑不出來。
Preliminary genomic characterisation and antimicrobial resistance of non-typhoidal Salmonella isolates from Burkina Faso within a One Health framework¶
Authors: Somda NS et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1743556 | PMID: 42466127
TL;DR: 布吉納法索34株疑似Salmonella enterica中21株確認，主要serovar為S. Schwarzengrund與S. Give各19.04%；部分株帶fosA7-4、sul2、tet(A)等AMR genes。
不嘻嘻：Salmonella serovar少，AMR劇情還是照演。
🟡 Food Security / Food Safety¶
Metal-organic frameworks nanozyme-integrated portable microneedle patch for visual bacterial monitoring in meat¶
Authors: Cheng J et al. | Journal: Food Chem | Date: 2026 Jul 13
DOI: 10.1016/j.foodchem.2026.150407 | PMID: 42462314
TL;DR: Fe/Cu-NBDC MOF nanozyme microneedle patch可在肉品中視覺偵測Staphylococcus aureus，detection limit 82 CFU/mL，整合採樣、富集與現場判讀。
嘻嘻：microneedle patch驗肉品，現場感十足。
Assessing the threat of Bacillus cereus: From toxin characterization to modern detection strategies¶
Authors: Tian R et al. | Journal: Food Chem | Date: 2026 Jul 14
DOI: 10.1016/j.foodchem.2026.150391 | PMID: 42462312
TL;DR: Bacillus cereus造成diarrheal與emetic foodborne illness；新virulence factors與detection technologies改善監測，但VBNC state、emetic toxin規範與臨床處置仍有缺口。
不嘻嘻：Bacillus cereus老問題，偵測進步也還沒收工。
Design of an innovative framework based hybrid catalyst for simultaneous and sensitive monitoring of food additive and preservative of vanillin and nitrite in direct samples¶
Authors: Arul P et al. | Journal: Food Chem | Date: 2026 Jul 12
DOI: 10.1016/j.foodchem.2026.150399 | PMID: 42462298
TL;DR: Ni-TPA-MOF/MoS2/Co3O4 electrochemical sensor可同步偵測vanillin與nitrite，linear range達nM至mM等級，LOD分別0.102 nM與0.073 nM，食品樣本回收率98.85–102.41%。
嘻嘻：食品添加物感測器越做越像科幻道具。
Integrated transcriptomic and metabolomic analyses reveal TPS1 as a key regulator linking cell wall integrity to aflatoxin production in Aspergillus flavus¶
Authors: Qi F et al. | Journal: Int J Food Microbiol | Date: 2026 Jul 10
DOI: 10.1016/j.ijfoodmicro.2026.111956 | PMID: 42462429
TL;DR: Aspergillus flavus TPS1 deletion使sclerotia完全消失、cell wall integrity受損並顯著降低AFB1；23個AFB1 biosynthetic cluster genes同步下調。
嘻嘻：抓到TPS1，aflatoxin控制多一個把手。
Sublethal cooking temperatures and simulated digestion: survival responses of Listeria monocytogenes and the emerging contaminant Acinetobacter spp¶
Authors: Carvalho M et al. | Journal: Int J Food Microbiol | Date: 2026 Jul 09
DOI: 10.1016/j.ijfoodmicro.2026.111947 | PMID: 42462425
TL;DR: 牛肉漢堡經55–65°C或≥70°C烹調後，L. monocytogenes與Acinetobacter spp.仍可存活並耐受模擬胃腸條件；strain 3524於>70°C後仍具高resilience。
不嘻嘻：漢堡熱處理後還能活，廚房信心又扣分。
Epidemiological analysis of pesticide poisoning cases in Zibo City, Shandong Province, China: a decade-long study (2014-2023)¶
Authors: Li N et al. | Journal: BMC Public Health | Date: 2026 Jul 16
DOI: 10.1186/s12889-026-28329-6 | PMID: 42464221
TL;DR: 中國山東淄博2014–2023年762例pesticide poisoning，CFR 17.6%；non-occupational intentional ingestion占68.9%且CFR 23.6%，死亡與年齡、女性、herbicide暴露相關。
不嘻嘻：pesticide poisoning資料背後是沉重的公共衛生題。
Carriage and susceptibility of Enterobacteria isolated from the local chickens at markets and peri-urban areas of Bobo-Dioulasso, Burkina Faso¶
Authors: Zon D et al. | Journal: BMC Microbiol | Date: 2026 Jul 16
DOI: 10.1186/s12866-026-05394-w | PMID: 42464141
TL;DR: 布吉納法索100隻健康本地雞分離株分子確認E. coli帶菌率53%、Salmonella 10%；amoxicillin與tetracycline抗藥率分別>93%、>80%，ESBL phenotype約36–40%。
不嘻嘻：健康雞帶菌又抗藥，市場監測不能裝沒事。
Variable fluid mechanics explain why static efficacy tests overestimate sanitizer performance against Listeria¶
Authors: Jiao Y et al. | Journal: Appl Environ Microbiol | Date: 2026 Jul 17
DOI: 10.1128/aem.00906-26 | PMID: 42466844
TL;DR: 100 ppm hypochlorite對Listeria innocua reduction高度受shear stress影響：spray impingement處降7.5 log，低shear區僅0.4 log，static coupon test會高估實務效能。
不嘻嘻：sanitizer實驗室很威，現場低shear就破功。
Goldenberry (Physalis peruviana L.) juice inhibits foodborne pathogens while promoting probiotic bacterial growth¶
Authors: Aladhadh M et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-57257-z | PMID: 42463768
TL;DR: 10% goldenberry juice在broth與milk中使L. monocytogenes、S. aureus、P. aeruginosa、E. coli下降1–3 log CFU/mL，並促進probiotic strains增加1–4 log。
嘻嘻：goldenberry juice看起來是益菌友善型狠角色。
A nutritionally-explicit test of the food-safety trade-off under predation risk¶
Authors: Banerjee A et al. | Journal: Sci Rep | Date: 2026 Jul 16
DOI: 10.1038/s41598-026-50887-3 | PMID: 42463496
TL;DR: 半戶外 enclosure中，predation risk使Psammophilus dorsalis活動下降並偏好靠近避難處覓食；macronutrient攝取差異有限，但元素保留隨風險暴露改變。
不嘻嘻：掠食風險連吃飯策略都要插手。
Adaptation to Sublethal Sodium Hypochlorite Enhanced Biofilm Formation of Salmonella Enteritidis on Food-Contact Surfaces¶
Authors: Liang Y et al. | Journal: Foodborne Pathog Dis | Date: 2026 Jul 17
DOI: 10.1177/15353141261469731 | PMID: 42466572
TL;DR: sublethal NaClO適應後，Salmonella Enteritidis在stainless steel與glass biofilm biomass增加，motility由7.73降至3.45 cm，auto-aggregation由25.42%升至39.12%。
不嘻嘻：低劑量NaClO像是在訓練Salmonella練biofilm。
資料來源：PubMed (articles retrieved 2026-07-18)