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Daily Journal Digest — 2026-07-15

過去 24 小時新增:Transplant ID × 20、One Health × 10、Food Security × 12,共 42 篇。

⭐ 今日亮點


🔬 深入評讀

Brucella canis in dogs: An underrecognized zoonotic pathogen requiring a one health response

One Health | IF 5.7 | DOI | PMID 42440889

  • 設計:這是一篇敘述性綜述,整理 Brucella canis 的 microbiology、流行病學、臨床表現、診斷限制與 One Health 應對框架。文章特別聚焦犬隻作為主要 reservoir、獸醫與人醫端診斷落差,以及跨部門監測不足。
  • 樣本:綜述引用近期全球 canine meta-analysis,涵蓋 175,675 份犬隻樣本;另引用人類病例 scoping review,共 68 例。犬隻資料橫跨不同地區與場域,並指出 breeding、kennel、shelter 等高密度環境風險較高。
  • 關鍵論點:近期全球 meta-analysis 估計犬隻 pooled prevalence 為 7.96%,但地理異質性很大;人類 scoping review 中,有已知暴露史者 80% 與直接接觸狗相關。文章的核心論點是 B. canis rough LPS phenotype 會使傳統 smooth-antigen serology 表現受限,導致獸醫與人醫端都可能低估感染。
  • Limitation:本文並非系統性回顧,未提供完整檢索策略、RoB 評估或證據分級,因此不同研究間的診斷標準、採樣族群與地理代表性難以直接比較。人類病例數少且高度仰賴已發表病例,可能有 underdiagnosis 與 publication bias。
  • Bottom line:對感染科而言,B. canis 應被視為低估的犬源 zoonosis;不明原因發燒或慢性非特異症狀合併犬隻暴露時,要記得傳統 Brucella serology 可能漏診,並推動人醫、獸醫與公衛端共同監測。

🔴 Transplant & Opportunistic Infections

Antifungal susceptibility profiles of clinical and environmental Scedosporium and Lomentospora isolates from Taiwan: focus on olorofim activity and phylogenetic heterogeneity

Authors: Lin SY et al. | Journal: J Antimicrob Chemother | Date: 2026 Jul 02
DOI: 10.1093/jac/dkag236 | PMID: 42444180

TL;DR: 台灣216株臨床與環境Scedosporium/Lomentospora中,olorofim MIC90皆≤0.12 mg/L;MIC變異72.5–89.2%在種內,仍需逐株susceptibility testing。

嘻嘻:olorofim看來很香,但逐株驗才安心。


Evaluation of Quantitative Differences of Classic Methods, Fungal Biomarkers, and T2Candida for Assessing the Central Venous Catheter Origin of Candidemia

Authors: Soriano-Martín A et al. | Journal: Open Forum Infect Dis | Date: 2026 Jul
DOI: 10.1093/ofid/ofag411 | PMID: 42444792

TL;DR: 28例candidemia中,BDG差值診斷CRC表現最佳,sensitivity 81.82%、specificity 82.35%;T2Candida與其他biomarkers sensitivity僅0–40%,不足以取代拔catheter。

不嘻嘻:catheter問題最後還是老派拔管最實在。


Amino acid substitutions at the G118 hotspot in dihydroorotate dehydrogenase confer olorofim resistance in Aspergillus flavus

Authors: Xu H et al. | Journal: Microbiol Spectr | Date: 2026 Jul 14
DOI: 10.1128/spectrum.00251-26 | PMID: 42446237

TL;DR: CRISPR point mutation證實A. flavus DHODH G118 substitutions造成olorofim resistance,且Galleria mellonella model未見明顯fitness cost,olorofim治療失效。

不嘻嘻A. flavus學壞還不付fitness cost,太會。


Plasma metagenomic sequencing testing for diagnosis of invasive fungal infection in children and young adults

Authors: Landa MM et al. | Journal: Microbiol Spectr | Date: 2026 Jul 14
DOI: 10.1128/spectrum.00699-26 | PMID: 42446199

TL;DR: 180名高風險兒童與年輕成人227次IFI疑慮中,plasma mNGS於36次送檢找出28次病原;對proven/probable IFI positive agreement 77.8%、negative 90.4%。

嘻嘻:plasma mNGS讓兒科IFI少一點盲猜。


Association between maintenance dialysis and tuberculosis treatment outcomes in Amazonas, Brazil: a population-based record-linkage cohort study (2001-2023) : Maintenance Dialysis and Tuberculosis Outcomes

Authors: Dos Santos SSB et al. | Journal: BMC Infect Dis | Date: 2026 Jul 13
DOI: 10.1186/s12879-026-13991-3 | PMID: 42443805

TL;DR: 巴西亞馬遜58,611例TB中,maintenance dialysis僅112例但不良結局風險大增(aOR 5.45, 95% CI 3.60–8.24);DOT具保護效果(aOR 0.67)。

不嘻嘻:dialysis遇上TB,預後直接開困難模式。


Positive Strongyloides Serology: A Descriptive Analysis Across Geographically Distinct Academic Medical Centers

Authors: Nagarakanti SR et al. | Journal: Transpl Infect Dis | Date: 2026 Jul 14
DOI: 10.1111/tid.70276 | PMID: 42446036

TL;DR: 412例Strongyloides IgG陽性者多為pretransplant evaluation,97.3%屬慢性感染;hyperinfection 2.42%、disseminated infection 0.24%,治療處方差異大。

不嘻嘻Strongyloides篩到了,治療習慣卻各走各路。


Role of zinc in growth, stress response and virulence gene expression of pathogenic Mucorale Rhizopus arrhizus

Authors: Singh R et al. | Journal: J Med Microbiol | Date: 2026 Jul
DOI: 10.1099/jmm.0.002184 | PMID: 42446527

TL;DR: zinc supplementation使Rhizopus arrhizus生長、代謝與細胞毒性上升,並上調mucoricin與iron transport genes;amphotericin B、posaconazole susceptibility未變。

不嘻嘻:給zinc後Mucorale更有精神,謝囉。


Production of virus-like particles with AsCas12a nuclease and CMV-driven crRNA for mammalian genome editing

Authors: Kruglova NA et al. | Journal: Front Genome Ed | Date: 2026
DOI: 10.3389/fgeed.2026.1735339 | PMID: 42445839

TL;DR: AsCas12a-VLPs以CMV-driven crRNA包裝RNP,小量與大量製程nuclease loading與editing相近,Jurkat T cells CXCR4 knockout最高達60%。

嘻嘻:Cas12a-VLP量產還穩,編輯工具箱又升級。


Clinicopathological Spectrum of Brain Parenchymal Infections: A Retrospective Analytical Study

Authors: Tiwari RG et al. | Journal: Cureus | Date: 2026 Jun
DOI: 10.7759/cureus.110777 | PMID: 42445634

TL;DR: 印度單中心12例brain parenchymal infections中,histopathology與臨床影像診斷一致率75%;25% discordant,凸顯組織診斷在neuroinfection仍關鍵。

不嘻嘻:neuroinfection最後常靠切片來打臉影像。


Context-dependent reprogramming of ALS adhesin expression in Candida albicans: a multi-inducer analysis linking morphogenesis to virulence plasticity

Authors: Ahmed R et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1848556 | PMID: 42445484

TL;DR: Candida albicans七個ALS genes在6種inducers下呈時間分層表現;ALS3於37°C glucose 6小時上升25.17倍,支持其作為anti-adhesion標靶。

嘻嘻Candida albicans黏附劇本越拆越清楚。


Refining cytokine signatures: flow cytometry-based differentiation between TB infection and disease

Authors: Doležalová K et al. | Journal: IJTLD Open | Date: 2026 Jul
DOI: 10.5588/ijtldopen.25.0781 | PMID: 42445219

TL;DR: 118名IGRA陽性者中,flow cytometry cytokine profiling顯示兒童TB可見CD8+ TNF-α較高;成人TBI有較高CD4+ IL-10,TB則CD4+ IL-2較高。

嘻嘻:cytokine指紋也許能幫TB分流更精準。


Nurse case management to improve multidrug-resistant TB: a cluster-randomised trial

Authors: Farley JE et al. | Journal: IJTLD Open | Date: 2026 Jul
DOI: 10.5588/ijtldopen.26.0126 | PMID: 42445215

TL;DR: 南非10家醫院2,134例MDR-TB中,nurse case management未提升治療成功率(64.5% vs 61.9%, aOR 0.79),但treatment failure下降44%(aOR 0.56)。

不嘻嘻:MDR-TB照護加碼,成功率還是不太賞臉。


Pulmonary cavitation as a dominant prognostic indicator in tuberculosis complicated by chronic pulmonary aspergillosis: a retrospective cohort study

Authors: Gao F et al. | Journal: J Thorac Dis | Date: 2026 Jun 30
DOI: 10.21037/jtd-2026-1-0393 | PMID: 42444884

TL;DR: 440例PTB合併CPA追蹤中位6個月,20%發生大量hemoptysis需手術或死亡;pulmonary cavitation為最強預後因子(HR 2.069)。

不嘻嘻:TB加CPA,有空洞就像預後警報器。


The State of Posttransplant Malignancies in Vascularized Composite Allotransplantation

Authors: Gursky AK et al. | Journal: Plast Reconstr Surg Glob Open | Date: 2026 Jul
DOI: 10.1097/GOX.0000000000007782 | PMID: 42444763

TL;DR: 15名VCA受贈者共24個malignancies,非melanoma skin cancer占60%、PTLD占33%;整體存活率53.3%,PTLD死亡率50%。

不嘻嘻:移植後malignancy這題仍然很難笑。


Discovery of novel anti-Toxoplasma gondii agent derived from thiazolidinone-isatin hybrids: synthesis, biological assessment, and computational modeling

Authors: Sabt A et al. | Journal: RSC Adv | Date: 2026 Jul 13
DOI: 10.1039/d6ra04647a | PMID: 42444701

TL;DR: 17個thiazolidinone-isatin hybrids中,4a對Toxoplasma gondii RH strain最強(IC50 0.21 µg/mL),Hs27 selectivity index >1171,in silico指向TgCDPK1。

嘻嘻:anti-Toxoplasma新骨架看起來滿有戲。


Clinicopathological Associations of Plasma Cell-Rich Rejection in Pediatric Liver Transplant Recipients

Authors: Gemell R et al. | Journal: Pediatr Transplant | Date: 2026 Jul
DOI: 10.1111/petr.70403 | PMID: 42444492

TL;DR: 91名兒童liver transplant recipients中,plasma cell-rich rejection占15.3%;recurrent rejection(OR 22.04)與severe rejection(OR 3.60)獨立相關,但非死亡因子。

不嘻嘻:rejection會反覆來,兒肝移植醫師很累。


Multimorbidity in adolescents in sub-Saharan Africa: a systematic review

Authors: Nzvere FP et al. | Journal: Commun Med (Lond) | Date: 2026 Jul 11
DOI: 10.1038/s43856-026-01751-y | PMID: 42443566

TL;DR: 撒哈拉以南非洲青少年multimorbidity systematic review僅納入12篇,盛行率0–13.8%;研究多未納入常見mental disorders,異質性高。

不嘻嘻:青少年multimorbidity資料少到像拼圖缺角。


Spinal Aspergillosis: Case Report

Authors: Bertašius V et al. | Journal: Int J Spine Surg | Date: 2026 Jul 13
DOI: 10.14444/8921 | PMID: 42443047

TL;DR: 42歲type 1 diabetes女性spinal aspergillosis因T. tuberculosis與voriconazole hepatotoxicity病程複雜,需多次debridement與C4–T7重建;9個月未復發但神經恢復有限。

不嘻嘻:spinal aspergillosis治完,神經不一定買單。


A Neonatal Intravenous Transplant Model for Assessment of Early-Life Immune Activities Against Cancer Cells

Authors: Aletaha M et al. | Journal: J Vis Exp | Date: 2026 Jun 26
DOI: 10.3791/69478 | PMID: 42441697

TL;DR: neonatal temporal vein injection在1–2日齡小鼠可穩定engraft luciferase-tagged pediatric cancer cells且無procedure-related mortality;murine CMV感染降低ALL burden但不影響NB。

嘻嘻:新生小鼠模型讓早期免疫題目更好問。


Next-generation LMP2A-targeting TCR-recombinant T cells with inducible IL-18 expression to treat EBV-associated malignancies

Authors: Bonifacius A et al. | Journal: Mol Ther Oncol | Date: 2026 Sep 17
DOI: 10.1016/j.omton.2026.201265 | PMID: 42440851

TL;DR: LMP2A-targeting iIL-18_TCR-T cells對HLA-A*02:01+ EBV-infected B-LCLs較傳統LMP2A_TCR-T cytotoxicity更佳,並在spheroid model持續控制腫瘤生長。

嘻嘻:iIL-18_TCR-T對EBV腫瘤很有戰鬥感。


🟢 One Health / Zoonoses

Divergent mechanisms of active antibiotic resistance gene enrichment in soil driven by pesticide diversity

Authors: Wang YF et al. | Journal: Nat Commun | Date: 2026 Jul 13
DOI: 10.1038/s41467-026-75445-3 | PMID: 42443210

TL;DR: 長期田間試驗顯示低、高pesticide diversity皆提高active ARG abundance;低diversity以A. baumannii efflux pump co-selection為主,高diversity則促進ROS/SOS與HGT。

不嘻嘻:pesticide一多,ARG也跟著開派對。


Rapid Expansion of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Genotype D1.1 Virus across Flyway Regions, North America, Fall 2024

Authors: Scotch M et al. | Journal: Emerg Infect Dis | Date: 2026 Jul 13
DOI: 10.3201/eid3208.260205 | PMID: 42442739

TL;DR: 北美HPAI A(H5N1) clade 2.3.4.4b genotype D1.1於2024秋季迅速擴張,phylodynamics支持太平洋flyway早期來源、中央flyway為次級hub。

不嘻嘻:H5N1飛越北美,流感監測又要加班。


Brucella canis in dogs: An underrecognized zoonotic pathogen requiring a one health response

Authors: Storoni C et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101506 | PMID: 42440889

TL;DR: Brucella canis犬隻pooled prevalence 7.96%,人類68例scoping review中已知暴露者80%與直接接觸狗相關;rough LPS使常規serology表現受限。

不嘻嘻Brucella canis低調到人狗都容易漏接。


First evidence of exposure to West Nile Virus in horses within Denmark, 2025

Authors: Ryt-Hansen P et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101505 | PMID: 42440749

TL;DR: 丹麥2025年822匹馬血清篩檢中,4匹無境外旅遊或WNV疫苗史者出現WNV neutralising antibodies,支持境內蚊媒暴露並可作人類風險sentinel。

不嘻嘻:丹麥馬匹先示警,蚊媒病毒不等人。


A One Health Gender Equality and Social Inclusion (OH GESI) Framework to strengthen equity goals of One Health implementation tools

Authors: Cediel-Becerra N et al. | Journal: One Health | Date: 2026 Dec
DOI: 10.1016/j.onehlt.2026.101493 | PMID: 42440386

TL;DR: OH-GESI framework檢視OHHLEP盤點的One Health工具,指出多數未充分處理gender equality與social inclusion,可用於將equity承諾轉為實作。

嘻嘻:One Health把公平納入工具,不只喊口號。


Animal husbandry and environmental conditions are associated with cefotaxime-resistant Escherichia coli in yard soil in peri-urban Malawi

Authors: Budden E et al. | Journal: PLOS Glob Public Health | Date: 2026
DOI: 10.1371/journal.pgph.0006264 | PMID: 42441539

TL;DR: 馬拉威237戶研究中,233份庭院土壤69%含cefotaxime-resistant E. coli;夜間圈養動物濃度低0.50 log,未圈養則高0.40 log。

不嘻嘻:院子土壤有抗藥E. coli,很不田園。


Efficacy and safety outcomes reported in human leptospirosis studies to inform the development of a core outcome and core outcome measurement set: A systematic review

Authors: Lee N et al. | Journal: PLoS Negl Trop Dis | Date: 2026 Jul 13
DOI: 10.1371/journal.pntd.0013651 | PMID: 42441728

TL;DR: human leptospirosis systematic review納入63國298篇,抽出172種outcomes、92種measures;mortality最常見(165/298),patient-focused與harms outcomes明顯不足。

不嘻嘻:leptospirosis研究outcome多到難以合唱。


Mechanisms of bovine Hunnivirus entry into MDBK cells

Authors: Qiao C et al. | Journal: Vet Microbiol | Date: 2026 Jul 10
DOI: 10.1016/j.vetmic.2026.111134 | PMID: 42442072

TL;DR: bovine Hunnivirus進入MDBK cells仰賴clathrin-mediated endocytosis與macropinocytosis,後者需NHE、PI3K與RTKs;不依賴caveolin-mediated endocytosis。

嘻嘻:Hunnivirus進門路線被拆解,基礎功補上。


Sensitive Detection of Foodborne Parasitic Larvae Using a Sieving-qPCR Workflow: Application to Angiostrongylus cantonensis

Authors: Kačmaříková J et al. | Journal: J Food Sci | Date: 2026 Jul
DOI: 10.1111/1750-3841.71260 | PMID: 42446021

TL;DR: sieving-qPCR流程可在50 g lamb's lettuce中穩定偵測1條Angiostrongylus cantonensis L3,sieve-retained material與sedimented flow-through皆可檢出。

嘻嘻:一條L3也抓得到,生菜檢驗安心些。


A time-delayed epidemic model for control of highly pathogenic avian influenza (HPAI H5Nx) with vaccination, compliance, and non-pharmaceutical interventions

Authors: Babasola O et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1819528 | PMID: 42440901

TL;DR: time-delayed HPAI H5Nx model顯示vaccine deployment與protection delay會削弱早期減峰效果;NPI立即降傳播,對outbreak初期影響最大。

不嘻嘻:HPAI疫苗慢半拍,NPI還是先上場。


🟡 Food Security / Food Safety

Suppression of Escherichia coli O157:H7 by Pseudomonas fluorescens A506 on romaine lettuce leaves is independent of iron competition

Authors: Xu T et al. | Journal: Int J Food Microbiol | Date: 2026 Jul 08
DOI: 10.1016/j.ijfoodmicro.2026.111955 | PMID: 42442321

TL;DR: romaine lettuce上先以P. fluorescens A506 colonization可使E. coli O157:H7在72小時下降1–2 log CFU/g;葉面抑制不主要來自iron competition。

嘻嘻:生菜上以菌制菌,居然不是靠搶iron。


Peer review of the pesticide risk assessment of the active substance flurochloridone

Authors: Álvarez F et al. | Journal: EFSA J | Date: 2026 Jul
DOI: 10.2903/j.efsa.2026.10185 | PMID: 42444744

TL;DR: EFSA完成flurochloridone用於馬鈴薯、向日葵與棉花的peer review,列出regulatory risk assessment end points、缺漏資料與concerns,供歐盟審查使用。

不嘻嘻:pesticide審查永遠是資料缺口的藝術。


Microbiological and physicochemical quality of locally processed agro-food products in Burkina Faso: assessing post-production supply chain vulnerabilities

Authors: Séré AP et al. | Journal: BMC Microbiol | Date: 2026 Jul 13
DOI: 10.1186/s12866-026-05376-y | PMID: 42443746

TL;DR: 布吉納法索30件本地加工食品PCA解釋76.9%變異,post-production vulnerability以Moringa oleifera leaf powder與hibiscus juice最高,honey、cottonseed oil、cashew最低。

不嘻嘻:加工後供應鏈一鬆,食品品質就破功。


Tracing and characterization of a family outbreak of subtype B2 botulism linked to homemade pickled eggs in Jinan, China

Authors: Cui W et al. | Journal: BMC Microbiol | Date: 2026 Jul 13
DOI: 10.1186/s12866-026-05390-0 | PMID: 42443745

TL;DR: 中國濟南4人家庭聚餐後3人botulism,qPCR、MBA與WGS確認自製醃蛋相關Clostridium botulinum subtype B2;病人、食品與土壤株高度相關。

不嘻嘻:自製醃蛋翻車,botulism不給面子。


Discovery and quantification of novel diazepam metabolites BP-246 and BP-271 in freshwater fish using HRMS and UPLC-MS/MS

Authors: Ouyang P et al. | Journal: Sci Rep | Date: 2026 Jul 13
DOI: 10.1038/s41598-026-61635-y | PMID: 42443319

TL;DR: 淡水魚肌肉中首次以HRMS發現diazepam metabolites BP-246與BP-271;UPLC-MS/MS驗證LOQ 0.15–0.20 µg/kg,10件市售陽性魚可見不同metabolite profiles。

不嘻嘻:魚肉驗出diazepam metabolites,晚餐也很迷幻。


Genetic diversity assessment of Bambara groundnut (Vigna subterranea (L.) Verdc.) along climatic gradients in Chad

Authors: Schneider M et al. | Journal: Sci Rep | Date: 2026 Jul 13
DOI: 10.1038/s41598-026-59833-9 | PMID: 42443295

TL;DR: 查德212份Bambara groundnut landraces中,172份分析顯示farm-level因素是主要變異來源(p<0.001),支持把農民selection納入breeding。

嘻嘻:農民selection進breeding,接地氣才有用。


Exploring Coffee By-Products as Alternative Protein Sources: A Comprehensive Analysis of Amino Acid Profiles (Free and Total) and Protein Quality

Authors: Machado M et al. | Journal: J Food Sci | Date: 2026 Jul
DOI: 10.1111/1750-3841.71304 | PMID: 42446020

TL;DR: 6種coffee by-products蛋白含量1.49–14.34%,silverskin最高;defective beans胺基酸最均衡且EAAI 91%,methionine為first limiting amino acid。

嘻嘻:咖啡副產物也能談蛋白,廢料翻身。


The Circles of Resilience model: exploring how social and structural conditions foster child resilience in the context of ACEs

Authors: Viglione C et al. | Journal: Front Public Health | Date: 2026
DOI: 10.3389/fpubh.2026.1802488 | PMID: 42440518

TL;DR: 聖地牙哥156組Latino mother-child dyads中,ACEs與較差child self-regulation相關(β=7.44),maternal anxiety部分中介;social connections緩衝ACEs-anxiety路徑。

嘻嘻:social connections真的能替孩子擋一點風。


Recent Advances in Detection Technologies for Melamine in Food Matrices

Authors: Meng Q et al. | Journal: Crit Rev Anal Chem | Date: 2026 Jul 14
DOI: 10.1080/10408347.2026.2701975 | PMID: 42446870

TL;DR: melamine食品檢測技術review指出chromatography與mass spectrometry仍為確認標準;新興光學、electrochemical與molecular recognition平台較快但受matrix interference與標準化不足限制。

不嘻嘻:melamine快篩很多,標準化還在追趕。


Exploring the Macin Family of Antimicrobial Peptides: Structure, Function, and Emerging Applications in Food Safety

Authors: Rana E et al. | Journal: Lett Appl Microbiol | Date: 2026 Jul 14
DOI: 10.1093/lambio/ovag059 | PMID: 42446411

TL;DR: macin family為含8個保守cysteine、4個disulfide bonds的AMPs,可透過聚集與membrane permeabilization抑制foodborne pathogens,具食品保存應用潛力。

嘻嘻:macin peptides讓食品保存多一把新刀。


Epidemiological features and antibiotic resistance of Salmonella strains isolated from diarrheal cases in Gansu Province, China, 2024

Authors: Lan G et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1791129 | PMID: 42445501

TL;DR: 中國甘肅91株Salmonella腹瀉分離株中,0–9歲占56.04%,MDR達80.22%;monophasic Salmonella Typhimurium 1,4,[5],12:i:-占34.07%,Enteritidis占25.27%。

不嘻嘻Salmonella MDR八成,腹瀉也會讓人心累。


Efficacy of Salmonella enterica phage SW03 and Escherichia coli O157:H7 phage CF03 in food matrices under storage conditions

Authors: Sallam O et al. | Journal: Front Microbiol | Date: 2026
DOI: 10.3389/fmicb.2026.1858265 | PMID: 42440938

TL;DR: phage SW03與CF03在牛肉、雞肉、lettuce於4與21°C皆能降低Salmonella entericaE. coli O157:H7,21°C lettuce 24小時最高下降約4.0與3.5 log CFU/g。

嘻嘻:phage在食物裡能打,冷藏熱放都有戲。


資料來源:PubMed (articles retrieved 2026-07-15)